WEKO3
アイテム
Proteolytic Cleavage of Various Human Serum Proteinase Inhibitors by Candida albicans Aspartic Proteinase
https://doi.org/10.15112/00005054
https://doi.org/10.15112/00005054be739ce2-666f-4786-a353-f28da66a1632
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
PDF (1.1 MB)
|
|
| Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2008-01-01 | |||||||||
| タイトル | ||||||||||
| タイトル | Proteolytic Cleavage of Various Human Serum Proteinase Inhibitors by Candida albicans Aspartic Proteinase | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Candida albicans aspartic proteinase | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | C1-inhibitor | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | α2-plasmin inhibitor | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | antithrombin III | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| ID登録 | ||||||||||
| ID登録 | 10.15112/00005054 | |||||||||
| ID登録タイプ | JaLC | |||||||||
| ページ属性 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | P(論文) | |||||||||
| 著者名(英) |
Tsushima, Hirofumi
× Tsushima, Hirofumi
× Mine, Hiroko
|
|||||||||
| 著者所属(英) | ||||||||||
| en | ||||||||||
| Laboratory for Medical Biology, Tsushima Clinic | ||||||||||
| 著者所属(英) | ||||||||||
| en | ||||||||||
| Department of Clinical Nutrition, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare | ||||||||||
| 抄録(英) | ||||||||||
| en | ||||||||||
| The secreted Candida albicans aspartic proteinase (SAP) is presumed to be one of the putative Candida virulence factors, while serum proteinase inhibitors depend on host defense mechanisms. We examined the interaction between SAP and serum proteinase inhibitors, such as C1-inhibitor, α2 plasmin inhibitor, and antithrombin III. SAP progressively inactivated plasmin inhibitory activity of C1-inhibitor and α2 plasmin inhibitor. It also inactivated thrombin inhibitory activity of antithrombin III. On sodium dodecyl sulfate-polyacrylamide gel electrophoresis, these host proteinase inhibitors were progressively degraded by SAP during prolonged incubation. These results suggest that SAP induces an imbalance of complements, coagulation and fibrinolytic systems through the degradation and inactivation of these host proteinase inhibitors, and that SAP may play an important role in the development of Candida albicans infections. | ||||||||||
| 書誌情報 |
en : Kawasaki journal of medical welfare 巻 13, 号 2, p. 59-65, 発行日 2008 |
|||||||||
| 公開者 | ||||||||||
| 出版者 | 川崎医療福祉学会 | |||||||||
| 雑誌書誌ID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA11108172 | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 1341-5077 | |||||||||
