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Effects of NK 1 and NMDA Receptor Antagonists on Severe Gagging Induced by Superior Laryngeal Nerve Stimulation in Rats
https://doi.org/10.15112/00005023
https://doi.org/10.15112/000050234ad6b5a6-5929-496c-89f8-fae773e29926
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
PDF (357.2 kB)
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| Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||||||
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| 公開日 | 2010-01-01 | |||||||||
| タイトル | ||||||||||
| タイトル | Effects of NK 1 and NMDA Receptor Antagonists on Severe Gagging Induced by Superior Laryngeal Nerve Stimulation in Rats | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | severe gagging | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | NK1 receptor | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | NMDA receptor | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | superior laryngeal nerve | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | decerebration | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| ID登録 | ||||||||||
| ID登録 | 10.15112/00005023 | |||||||||
| ID登録タイプ | JaLC | |||||||||
| ページ属性 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | P(論文) | |||||||||
| 著者名(英) |
Yamagata, Ryuzo
× Yamagata, Ryuzo
× Koga, Tomoshige
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| 著者所属(英) | ||||||||||
| en | ||||||||||
| Doctoral Program in Rehabilitation, Graduate School of Health Science and Technology, Kawasaki University of Medical Welfare | ||||||||||
| 著者所属(英) | ||||||||||
| en | ||||||||||
| Department of Rehabilitation, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare | ||||||||||
| 抄録(英) | ||||||||||
| en | ||||||||||
| Severe gagging, which is considered to be one of the emetic responses, prevents food bolus from being lodged in the pharyngo-laryngeal region. Little is known about the neuronal mechanism of severe gagging, because severe gagging is difficult to induce in animal experiments. In a recent study the authors reported that pulse train stimulation of the superior laryngeal nerve (SLN) at high frequency can be used to induce severe gagging in decerebrate rats. The present study was focused on the roles of NK_1 and NMDA receptors in severe gagging and the influence that the receptor antagonists may exert on this process. Intravenous administration of WIN51708, NK_1 receptor antagonist, significantly diminished the probability of the induction of severe gagging elicited by 3 sets of pulse train of the SLN at intervals of 1.7 sec (100Hz, 0.3ms, 50pulses, n=7). Similarly, MK-801, NMDA receptor antagonist, significantly diminished the probability of the induction of severe gagging (n=9). These results suggest that the neural circuits of severe gagging elicited by SLN stimulation could involve both NK_1 and NMDA receptors. Possible action sites of their antagonists in medulla oblongata were discussed and compared with other emetic responses. | ||||||||||
| 書誌情報 |
en : Kawasaki journal of medical welfare 巻 16, 号 1, p. 1-8, 発行日 2010 |
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| 公開者 | ||||||||||
| 出版者 | 川崎医療福祉学会 | |||||||||
| 雑誌書誌ID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA11108172 | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 1341-5077 | |||||||||
