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<Original Paper>The Voltage Sensitive Ca^<2+>-Channel Blocker Affected the Ca^<2+>-Release from Ca^<2+>-Channel of the Sarcoplasmic Reticulum Membrane in the Skeletal Muscle
https://doi.org/10.15112/00000022
https://doi.org/10.15112/0000002233b97f64-9de3-44b8-9aa9-fcf3e0f6068e
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
PDF (333.9 kB)
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| Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||||
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| 公開日 | 1995-01-01 | |||||||
| タイトル | ||||||||
| タイトル | <Original Paper>The Voltage Sensitive Ca^<2+>-Channel Blocker Affected the Ca^<2+>-Release from Ca^<2+>-Channel of the Sarcoplasmic Reticulum Membrane in the Skeletal Muscle | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | skeletal muscle | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | Dihydropyridine | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | sarcoplasmic reticulum | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | voltage dependent Ca-channel | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | Ca-release channel | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| ID登録 | ||||||||
| ID登録 | 10.15112/00000022 | |||||||
| ID登録タイプ | JaLC | |||||||
| ページ属性 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | P(論文) | |||||||
| 著者名(英) |
NISHIJIMA, Hiroaki
× NISHIJIMA, Hiroaki
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| 著者所属(英) | ||||||||
| en | ||||||||
| Department of Health & Sports Sciences, Faculty of Medical Professions Kawasaki University of Medical Welfare | ||||||||
| 抄録(英) | ||||||||
| en | ||||||||
| The effects of nicardipine as the Ca-antagonist in the dihydropyridine receptor (DHPR) of the transverse (T) tubular voltage sensor (Ca^<2+>channel) were studied in isolated frog skeletal muscle fibers. Nicardipine suppressed the twitch tension about 40% with repeated tetanic stimulation, and suppressed more than 80% with repeated applications of high potassium. When caffeine contracture on the nicardipine treated muscle fibers was induced by concentrations of lower than 5 mM caffeine, an inhibitory effect was seen with repeated tetanic stimulation, .On the contrary, an activation effect was seen on the nicardipine treated muscle fibers with repeated potassium deporalization.However, caffeine contracture with concentrations of more than 5 mM had not the different effects on the both nicardipine treated muscles. These results show that the voltage sensor in the T-tubular membranes has influence on the Ca-release from sarcoplasmic reticulum (SR) with caffeine, and was suggested that the SR membranes has the Ca induced Ca release channels which was inhibited by the voltage sensor on the T-tubles. | ||||||||
| 書誌情報 |
en : Kawasaki journal of medical welfare 巻 1, p. 131-136, 発行日 1995 |
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| 公開者 | ||||||||
| 出版者 | 川崎医療福祉学会 | |||||||
| 雑誌書誌ID | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA11108172 | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 1341-5077 | |||||||
