| Item type |
紀要論文(ELS) / Departmental Bulletin Paper(1) |
| 公開日 |
2019-02-22 |
| タイトル |
|
|
タイトル |
Evaluation of the Effects of Frequent Alcohol Administration on Liver Function in Partially Hepatectomized Rats: Serum Changes |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
liver transplantation |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
partial hepatectomy |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
alcohol |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
alcoholic liver disease |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
serum lipid level |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| ID登録 |
|
|
ID登録 |
10.15112/00014506 |
|
ID登録タイプ |
JaLC |
| ページ属性 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
P(論文) |
| 著者名(英) |
OKAMURA, Yurika
ONO, Hisami
ONO, Akifumi
|
| 著者所属(英) |
|
|
|
en |
|
|
Faculty of Medical Nutrition, Hiroshima International University |
| 著者所属(英) |
|
|
|
en |
|
|
Department of Human Nutrition, Faculty of Contemporary Life Science, Chugoku Gakuen University |
| 著者所属(英) |
|
|
|
en |
|
|
Department of Clinical Nutrition, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare |
| 抄録(英) |
|
|
|
en |
|
|
Alcohol toxicity effects in the liver regeneration process have been reported, but the effect of alcohol toxicity on the residual liver after partial hepatectomy (PH) has not yet been elucidated. We investigated whether or not the residual liver recovered to normal functional levels against the toxicity of alcohol after hepatectomy during liver regeneration. The partial hepatectomy group (the PH + C) showed increased cholesterol synthesis, but alcohol intake suppressed the increase. These results suggest that even if the same level of total energy is obtained, the liver activity required for its regeneration is suppressed by alcohol. The serum triglyceride concentrations of the alcohol- administered rats that underwent the sham operation were significantly elevated at 12 and 24 postoperative weeks (p<0.05). In the PH + A group, each TG level was lower than that in the A group. In addition, an indication of liver damage, serum AST, significantly increased 24 weeks after hepatectomy. In conclusion, alcohol consumption after PH causes liver damage as indicated by biochemical changes, and its long-term consumption can cause greater irreversible damage. Therefore, alcohol administration after hepatectomy obstructed the return of the liver function to its original level. |
| 記事種別(英) |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Original Paper |
| 書誌情報 |
en : Kawasaki journal of medical welfare
巻 24,
号 1,
p. 17-25,
発行日 2018
|
| 公開者 |
|
|
出版者 |
川崎医療福祉学会 |
| 雑誌書誌ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11108172 |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1341-5077 |
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