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Intra-gastric triacetin alters upper gastrointestinal motility in conscious dogs.
https://kwmw.repo.nii.ac.jp/records/13665
https://kwmw.repo.nii.ac.jp/records/13665d9df6d08-01dd-43a2-bf1d-2736e0ef3160
| 名前 / ファイル | ライセンス | アクション |
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PDF (1.2 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
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| 公開日 | 2014-09-30 | |||||||||||
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| タイトル | Intra-gastric triacetin alters upper gastrointestinal motility in conscious dogs. | |||||||||||
| 言語 | en | |||||||||||
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| 言語 | eng | |||||||||||
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| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Gastrointestinal motility | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Barostat | |||||||||||
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| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Proximal gastric relaxation | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Short-chain triglycerides | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| ページ属性 | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | P(論文) | |||||||||||
| 著者名(英) |
Oosaka, Kazumasa
× Oosaka, Kazumasa
× Tokuda, Masaaki
× Furukawa, Naohiro
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| 著者所属(英) | ||||||||||||
| en | ||||||||||||
| Research and Development Department, Fushimi Pharmaceutical Co., Ltd. | ||||||||||||
| 著者所属(英) | ||||||||||||
| en | ||||||||||||
| Department of Cell Physiology, Faculty of Medicine, Kagawa University | ||||||||||||
| 著者所属(英) | ||||||||||||
| en | ||||||||||||
| Department of Clinical Nutrition, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare | ||||||||||||
| 抄録(日) | ||||||||||||
| AIM: To examine the effect of intra-gastric triacetin on both upper gastrointestinal motility and proximal gastric tone in conscious dogs. METHODS: Three beagle dogs under sedation were surgically implanted with gastrocutaneous fistula in the gastric body and force transducers in the gastric antrum and duodenum. Beginning at week-2 after insertion, the animals were either fasted for 24 h or fed a liquid meal 2-3 h before the experiment. With the animals fully conscious, a polyethylene bag was inserted into the proximal stomach through the gastrocutaneous fistula, followed by 15 min of air inflation (minimal distending pressure of ＋2 mmHg) and then 20 mL of a low-, mid- or high-concentration triacetin solution (0.5%, 1.0% and 2.0%) or warm water (vehicle control). The proximal stomach receptive volume and gastric antral and duodenal contractions were measured over 10 min. The experiment was repeated twice per week over several months, with each animal receiving at least one infusion of the various triacetin solutions and the vehicle at different times. Intergroup differences were assessed by ANOVA and Bonferroni-Dunn post-hoc testing. RESULTS: Intra-gastric infusion of mid- and high-concentration triacetin induced an increase in the proximal stomach receptive volume, and the average increase induced by the high-concentration at 0-4 min after infusion was significantly greater than that induced by the vehicle control (62.4 ± 9.8 vs 18.4 ± 4.7, p < 0.01). The mid- and high-concentration triacetin also produced a temporary inhibition of the gastric antral contractions at 2 min after infusions; however, only the fasted group showed triacetin-induced antral contractile inhibition that was significantly greater than that in the vehicle control group (p < 0.05). In addition, only the fasted group showed a high-concentration triacetininduced increase in duodenal contractions at 9-10 min that was significantly different from that in the vehicle control group (p < 0.05). CONCLUSION: Intra-gastric infusion of 1.0%-2.0% triacetin delays gastric emptying by increasing proximal stomach receptive volume, temporarily inhibiting gastric antral contractions and facilitating duodenal contractions. |
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| 書誌情報 |
en : World journal of gastroenterology 巻 20, 号 4, p. 1054-1060, 発行日 2014 |
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| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 2219-2840 | |||||||||||
| 書誌レコードID | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA11690631 | |||||||||||
| PubMed番号 | ||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||
| 識別子タイプ | PMID | |||||||||||
| 関連識別子 | 24574778 | |||||||||||
| DOI | ||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | 10.3748/wjg.v20.i4.1054 | |||||||||||
| 著者版フラグ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
