| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2014-06-05 |
| タイトル |
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タイトル |
Types of programmed cell death: two variants expressed by neonatal murine hepatocytes. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
programmed cell death |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
apoptosis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
hepatocyte |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
neonatal mouse |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ページ属性 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
P(論文) |
| 著者名(英) |
Sasaki, Kazunobu
Sonoda, Yuji
Kumano, Ichiro
Suda, Masumi
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| 著者所属(英) |
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|
en |
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Department of anatomy, Kawasaki medical school |
| 著者所属(英) |
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|
|
en |
|
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Department of anatomy, Kawasaki medical school |
| 著者所属(英) |
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|
en |
|
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Department of anatomy, Kawasaki medical school |
| 著者所属(英) |
|
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|
en |
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Department of anatomy, Kawasaki medical school |
| 抄録(英) |
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|
en |
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Neonatal livers examined with the terminal transferase-mediated dUTP nick end labeling (TUNEL) method contained numerous positive cells. Although the majority of dying cells are either hematopoietic cells including erythroids and granulocytes or macrophages, a few hepatocytes were also positive. As for the ultrastructural features of these dying hepatocytes, two different types, type I and II, could be identified. The early features of type I appeared in the cytoplasm, which was characterized by dilated rough endoplasmic reticulum, and the cell fragments displayed a round, foamy appearance. Type II was characterized by nuclear compaction and margination of heterochromatin resulting in the formation of sharply circumscribed masses, followed by the condensation of the cytoplasm. The cell death of type I, characterized by the formation of massive vacuolization of the endoplasmic reticulum, corresponds to cytoplasmic type degeneration or nonapoptotic death, while that of type II corresponds to nuclear type cell death or classical apoptotic death. In the two types of programmed cell death, the incidence of nonapoptotic cell death was much higher than that of classical apoptosis in neonatal murine hepatocytes. |
| 書誌情報 |
en : Cells Tissues Organs
巻 175,
号 1,
p. 34-42,
発行日 2003
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| 出版者 |
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出版者 |
Karger |
| 公開者 |
|
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出版者 |
Author |
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1422-6405 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11324098 |
| DOI |
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|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.1159/000073435 |
| 権利 |
|
|
権利情報 |
http://www.karger.com/Article/FullText/73435 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
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