{"created":"2025-06-11T04:56:11.026643+00:00","id":2000360,"links":{},"metadata":{"_buckets":{"deposit":"23040945-4f27-499d-b632-0b09575ca300"},"_deposit":{"created_by":25,"id":"2000360","owner":"25","owners":[25],"pid":{"revision_id":0,"type":"depid","value":"2000360"},"status":"published"},"_oai":{"id":"oai:kwmw.repo.nii.ac.jp:02000360","sets":["7:1747876464809:1747877203116"]},"author_link":[],"item_1_alternative_title_20":{"attribute_name":"item_1_alternative_title_20","attribute_value_mlt":[{"subitem_alternative_title":"Study on the Mechanism of Elevated Serum Copper Levels in Rats with Adenine-induced Chronic Kidney Disease","subitem_alternative_title_language":"en"}]},"item_1_biblio_info_14":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2025","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"244","bibliographicPageStart":"237","bibliographicVolumeNumber":"34","bibliographic_titles":[{"bibliographic_title":"川崎医療福祉学会誌","bibliographic_titleLang":"ja"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中村, 博範","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"三宅, 沙知","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"瀬部, 真由","creatorNameLang":"ja"}]}]},"item_1_description_1":{"attribute_name":"item_1_description_1","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_2":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_1_full_name_7":{"attribute_name":"著者別名","attribute_value_mlt":[{"names":[{"name":"NAKAMURA, Hironori","nameLang":"en"}]},{"names":[{"name":"MIYAKE, Sachi","nameLang":"en"}]},{"names":[{"name":"SEBE, Mayu","nameLang":"en"}]}]},"item_1_identifier_registration":{"attribute_name":"identifier_registration","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15112/0002000360","subitem_identifier_reg_type":"JaLC"}]},"item_1_publisher_23":{"attribute_name":"item_1_publisher_23","attribute_value_mlt":[{"subitem_publisher":"川崎医療福祉学会","subitem_publisher_language":"ja"}]},"item_1_source_id_13":{"attribute_name":"item_1_source_id_13","attribute_value_mlt":[{"subitem_source_identifier":"AN10375470","subitem_source_identifier_type":"NCID"}]},"item_1_source_id_19":{"attribute_name":"item_1_source_id_19","attribute_value_mlt":[{"subitem_source_identifier":"0917-4605","subitem_source_identifier_type":"PISSN"}]},"item_1_text_22":{"attribute_name":"item_1_text_22","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Kawasaki medical welfare journal"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"川崎医療福祉大学医療技術学部臨床栄養学科"},{"subitem_text_language":"ja","subitem_text_value":"川崎医療福祉大学医療技術学部臨床栄養学科"},{"subitem_text_language":"ja","subitem_text_value":"川崎医療福祉大学医療技術学部臨床栄養学科"}]},"item_1_textarea_11":{"attribute_name":"item_1_textarea_11","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"慢性腎臓病（CKD）患者では血清銅濃度が上昇することが報告されている．しかしながら，CKDで⾎清銅濃度が上昇する機序については依然として不明である．⾎清銅の大部分はセルロプラスミン（CP）の銅に由来することから，血清銅の上昇はCP の変化を反映している可能性がある．そこで，本研究では，アデニン誘発慢性腎臓病ラットの血清銅とCP 濃度を評価した．8週齢の雄性Wister 系ラットを，0.25％アデニン添加飼料群（AD 群，6匹）と標準飼料群（C 群，6匹）の2群に分け，それぞれの飼料を8週間与えた．C 群と比較して，AD 群は血清クレアチニン，尿素窒素，リン濃度が有意に高く，全血ヘモグロビンが有意に低かった．血清銅とCP はAD 群で有意に高く，またC 反応性蛋白（CRP）値はAD 群で有意に高かった．銅とCP はCRP と正の相関を示した．CP の合成は炎症によって亢進することから，CKD における血清銅の上昇は慢性炎症によるCP 合成の増加と関連していると考えられた．"}]},"item_1_textarea_12":{"attribute_name":"item_1_textarea_12","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"Serum copper levels have been reported to be elevated in patients with chronic kidney disease (CKD). However, the mechanism of elevated serum copper concentrations in CKD is not yet clear. Since most of the copper in serum is derived from copper in ceruloplasmin (CP), elevated serum copper levels may reflect changes in CP. In this study, serum copper and CP levels were evaluated in adenine-induced chronic kidney disease rats. Eight-week-old male Wistar rats were divided into two groups: a 0.25 ％ adenine supplemented diet group (AD group, 6 rats) and a standard diet group (C group, 6 rats), and each diet was fed for 8 weeks. Compared with group C, the AD group had significantly higher serum creatinine, urea nitrogen, and phosphorus concentrations, and significantly lower whole blood hemoglobin. Serum copper and CP were significantly higher in the AD group, and C-reactive protein (CRP) levels were also significantly higher in the AD group. Copper and CP showed a positive correlation with CRP. Since CP synthesis is enhanced by inflammation, the increase in serum copper in CKD was thought to be due to the increase in CP associated with inflammation."}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-06-11"}],"displaytype":"detail","filename":"10_中村博範.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_note","url":{"label":"PDF","url":"https://kwmw.repo.nii.ac.jp/record/2000360/files/10_中村博範.pdf"},"version_id":"86f7f143-db44-43d1-b6c7-40ed49001bd6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"copper","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ceruloplasmin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"chronic kidney disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"rat","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"adenine","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"アデニン誘発性慢性腎臓病ラットにおける 血清銅濃度の上昇機序に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アデニン誘発性慢性腎臓病ラットにおける 血清銅濃度の上昇機序に関する研究","subitem_title_language":"ja"}]},"item_type_id":"1","owner":"25","path":["1747877203116"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-06-11"},"publish_date":"2025-06-11","publish_status":"0","recid":"2000360","relation_version_is_last":true,"title":["アデニン誘発性慢性腎臓病ラットにおける 血清銅濃度の上昇機序に関する研究"],"weko_creator_id":"25","weko_shared_id":-1},"updated":"2025-06-11T05:04:54.888623+00:00"}