| Item type |
紀要論文(ELS) / Departmental Bulletin Paper(1) |
| 公開日 |
2025-05-29 |
| タイトル |
|
|
タイトル |
Dietary Intervention Outperforms Fecal Microbiota Transplantation from Exercised and/or Lean Donors in Improving Metabolic Phenotypes of Western Diet-fed Obese Mice |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
fecal microbiota transplantation |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
exercise |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
dietary change |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
obesity |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
western diet |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| ID登録 |
|
|
ID登録 |
10.15112/0002000302 |
|
ID登録タイプ |
JaLC |
| item_1_description_1 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
P(論文) |
|
言語 |
en |
| 著者名(英) |
YODA, Takeshi
HAMADA, Hiroki
AOKI, Takafumi
WATANABE, Chihiro
OYANAGI, Eri
YAMAGATA, Takashi
YANO, Hiromi
KAWASHIMA, Masato
|
| 著者所属(英) |
|
|
|
en |
|
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Department of Health and Sports Science, Faculty of Health Science and Technology Kawasaki University of Medical Welfare・Department of Public Health, Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
|
Department of Health and Sports Science, Faculty of Health Science and Technology Kawasaki University of Medical Welfare |
| 著者所属(英) |
|
|
|
en |
|
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Department of Clinical Nutrition, Faculty of Health Science and Technology Kawasaki University of Medical Welfare |
| 著者所属(英) |
|
|
|
en |
|
|
Department of Health and Sports Science, Faculty of Health Science and Technology Kawasaki University of Medical Welfare |
| 著者所属(英) |
|
|
|
en |
|
|
Department of Health and Sports Science, Faculty of Health Science and Technology Kawasaki University of Medical Welfare |
| 著者所属(英) |
|
|
|
en |
|
|
Department of Health and Sports Science, Faculty of Health Science and Technology Kawasaki University of Medical Welfare |
| 著者所属(英) |
|
|
|
en |
|
|
Department of Health and Sports Science, Faculty of Health Science and Technology Kawasaki University of Medical Welfare |
| 著者所属(英) |
|
|
|
en |
|
|
Department of Health and Sports Science, Faculty of Health Science and Technology Kawasaki University of Medical Welfare |
| item_1_textarea_12 |
|
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|
en |
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The aim of the present study was to examine whether or not fecal microbiota transplantation (FMT) from exercised donor mice promotes the dietary change-induced improvements in the metabolic phenotypes of western diet-fed obese mice. Four-week-old male C57BL/6J mice, fed with a western diet for 12 weeks, were assigned to one of four groups: the continuous western diet without FMT (W-W), dietary switch to standard chow without FMT (W-S), dietary switch with FMT from sedentary lean donors (W-S+SedT), and dietary switch with FMT from exercised lean donors (W-S+ExT). FMT was performed daily for 4 weeks after antibiotic treatment. A shift in diet from a western diet to standard chow in the W-S, W-S+SedT, and W-S+ExT groups resulted in improvements in obesity, circulating metabolic parameters, and glucose metabolism. The cecal content of short-chain fatty acids was increased with the dietary intervention. However, the FMT
from lean and/or exercised donors did not potentiate the improvements in obese phenotypes caused by the dietary change. These results suggest that dietary interventions exert the most significant influence on ameliorating obesity-related disorders, while FMT from exercised donors may not yield additional benefits. |
| 記事種別(英) |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Original Paper |
|
言語 |
en |
| bibliographic_information |
en : Kawasaki journal of medical welfare
巻 30,
号 1,
p. 25-34,
発行日 2024
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| item_1_publisher_23 |
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出版者 |
川崎医療福祉学会 |
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言語 |
ja |
| item_1_source_id_13 |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11108172 |
| item_1_source_id_19 |
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収録物識別子タイプ |
PISSN |
|
収録物識別子 |
1341-5077 |
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