{"created":"2023-10-21T03:02:47.956650+00:00","id":2000025,"links":{},"metadata":{"_buckets":{"deposit":"28e34fe5-4f2c-43b0-92a3-696279b6c32f"},"_deposit":{"created_by":26,"id":"2000025","owner":"26","owners":[26],"pid":{"revision_id":0,"type":"depid","value":"2000025"},"status":"published"},"_oai":{"id":"oai:kwmw.repo.nii.ac.jp:02000025","sets":["7:1697248399292:1697248593634"]},"author_link":[],"control_number":"2000025","item_1_alternative_title_20":{"attribute_name":"その他(別言語等)のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Investigation of Effective in vitro Addition of a Novel MEK1/2 Inhibitor Binimetinib in Human Hematopoietic Tumor Cell Lines","subitem_alternative_title_language":"en"}]},"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"73","bibliographicPageStart":"69","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"川崎医療福祉学会誌","bibliographic_titleLang":"ja"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"榊原, 佳奈枝","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"通山, 薫","creatorNameLang":"ja"}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_2":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"短報","subitem_description_type":"Other"}]},"item_1_full_name_7":{"attribute_name":"著者別名","attribute_value_mlt":[{"names":[{"name":"SAKAKIBARA, Kanae"}]},{"names":[{"name":"TOHYAMA, Kaoru"}]}]},"item_1_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15112/0002000025","subitem_identifier_reg_type":"JaLC"}]},"item_1_publisher_23":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"川崎医療福祉学会"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN10375470","subitem_source_identifier_type":"NCID"}]},"item_1_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0917-4605","subitem_source_identifier_type":"PISSN"}]},"item_1_text_22":{"attribute_name":"その他(別言語)の雑誌名","attribute_value_mlt":[{"subitem_text_value":"Kawasaki medical welfare journal"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"川崎医療福祉大学 医療技術学部 臨床検査学科"},{"subitem_text_value":"川崎医科大学 検査診断学"}]},"item_1_textarea_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_textarea_value":"われわれは以前,ヒト造血器腫瘍細胞株における binimetinib の増殖抑制効果を確認したが,その際は培養初日の薬剤1回添加のみで検討していた.そこで今回,連日添加の効果を検討したところ,F36P を除くすべての細胞株において増殖抑制効果の増強は認められなかった.したがって,binimetinib の添加は基本的に初日の1回添加で十分であり,それで増殖抑制効果の乏しい細胞には複数回の添加を行ってもほとんど効果はないと考えられる.ただし,将来臨床応用に向けて\nbinimetinib の適正な投与方法を確立するためには,高濃度での連日添加などさらなる検討が必要である."}]},"item_1_textarea_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_value":"We previously confirmed the growth inhibitory effect of binimetinib in human hematopoietic tumor cell lines in vitro , but only a single addition of the drug on the first day of culture was investigated. In this study, we examined the effect of daily addition of binimetinib and found no increase in growth inhibition in all cell lines except F36P. This result suggests that a single addition of binimetinib on the first day is basically sufficient, and multiple additions to the cells showing resistance to the drug have little effect. Further in vitro studies are needed for aiming at future clinical use."}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-10-21"}],"displaytype":"detail","filename":"10_榊原佳奈枝.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PDF","url":"https://kwmw.repo.nii.ac.jp/record/2000025/files/10_榊原佳奈枝.pdf"},"version_id":"977d3288-55b8-42a2-a106-e441621391df"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"binimetinib","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cell line","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"MTT assay","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"flow cytometry","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ヒト造血器腫瘍細胞株における新規 MEK1/2阻害薬binimetinibの効果的投与方法の探索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト造血器腫瘍細胞株における新規 MEK1/2阻害薬binimetinibの効果的投与方法の探索","subitem_title_language":"ja"}]},"item_type_id":"1","owner":"26","path":["1697248593634"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-10-21"},"publish_date":"2023-10-21","publish_status":"0","recid":"2000025","relation_version_is_last":true,"title":["ヒト造血器腫瘍細胞株における新規 MEK1/2阻害薬binimetinibの効果的投与方法の探索"],"weko_creator_id":"26","weko_shared_id":-1},"updated":"2024-05-13T00:48:58.158228+00:00"}