{"created":"2023-06-19T10:05:26.442915+00:00","id":14918,"links":{},"metadata":{"_buckets":{"deposit":"68deb1f9-61b4-4c77-af6f-0aa2f9c7f54f"},"_deposit":{"created_by":23,"id":"14918","owners":[23],"pid":{"revision_id":0,"type":"depid","value":"14918"},"status":"published"},"_oai":{"id":"oai:kwmw.repo.nii.ac.jp:00014918","sets":["7:339:340"]},"author_link":["65408","65409","65410","65411"],"control_number":"14918","item_1_alternative_title_20":{"attribute_name":"その他(別言語等)のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Redox State of Plasma Albumin in Rats with Adenine-induced Chronic Kidney Disease","subitem_alternative_title_language":"en"}]},"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"149","bibliographicPageStart":"139","bibliographicVolumeNumber":"31","bibliographic_titles":[{"bibliographic_title":"川崎医療福祉学会誌"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中村, 博範","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"三宅, 沙知","creatorNameLang":"ja"}],"nameIdentifiers":[{}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_2":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著","subitem_description_type":"Other"}]},"item_1_full_name_7":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"NAKAMURA, Hironori"}]},{"nameIdentifiers":[{}],"names":[{"name":"MIYAKE, Sachi"}]}]},"item_1_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15112/00014848","subitem_identifier_reg_type":"JaLC"}]},"item_1_publisher_23":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"川崎医療福祉学会"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN10375470","subitem_source_identifier_type":"NCID"}]},"item_1_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0917-4605","subitem_source_identifier_type":"PISSN"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Clinical Nutrition Faculty of Health Science and Technology Kawasaki University of Medical Welfare"},{"subitem_text_language":"en","subitem_text_value":"Department of Clinical Nutrition Faculty of Health Science and Technology Kawasaki University of Medical Welfare"}]},"item_1_text_22":{"attribute_name":"その他(別言語)の雑誌名","attribute_value_mlt":[{"subitem_text_value":"Kawasaki medical welfare journal"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"川崎医療福祉大学医療技術学部臨床栄養学科"},{"subitem_text_value":"川崎医療福祉大学医療技術学部臨床栄養学科"}]},"item_1_textarea_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_textarea_value":"慢性腎臓病（CKD）の患者では酸化型アルブミンの比率が増加し，還元型アルブミンの比率が減少することが報告されている．しかし，その原因はまだ分かっていない．一方，CKDモデルラットでの検討はなく，CKDモデルラットをこの研究に応用できるかは不明である．そこで，本研究では， アデニン誘発性CKDモデルラットを作製し，腎機能とアルブミンの酸化還元状態との関係について調べた．Wistar系雄性ラットを3群に分け，以下の条件にて28日間飼育した．通常群（ST群）は標準飼料を自由に与え，アデニン群（AD群）はアデニンを0.25% 添加した飼料を自由に与えた．また， ペアフィーディング群（PF群）はAD群の摂取量に合わせて標準飼料を与えた．最終日に24時間尿を採取したあと，一晩絶食させ，血液と臓器を採取した．AD群は，ST群，PF群と比較して，血漿ク レアチニンと尿素窒素は有意に高く，クレアチニンクリアランスと血中ヘモグロビンは有意に低かった．したがって，AD群では腎機能の有意な低下が認められた．また，AD群は，PF群と比較して， 酸化型アルブミンの比率の有意な増加と，還元型アルブミンの比率の有意な低下が認められた．これらの結果は，CKDモデルラットでのアルブミンの酸化還元状態の変化はCKD患者と同じであることを示した．"}]},"item_1_textarea_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"Patients diagnosed with chronic kidney disease（CKD）have increased ratios of oxidized albumin and decreased ratios of reduced albumin, however, the cause for which remains unclear. In addition, it is also unclear whether the CKD rat model can be applied to this study. Therefore, we investigated the relationship between renal function and the redox state of albumin in rats with adenine-induced CKD. Male Wistar rats were divided into three groups and maintained for 28 days. The standard（ST）group was fed a standard diet, the adenine（AD）group was fed a diet supplemented with 0.25% adenine, and the pair-feeding（PF）group was fed a standard diet to match the intake of the AD group. Plasma creatinine and urea nitrogen levels were significantly higher, and creatinine clearance and blood hemoglobin were significantly lower in the AD group than in the ST and PF groups. There was a significant decrease in renal function in the AD group. Additionally, the ratio of oxidized albumin increased significantly, whereas the ratio of reduced albumin decreased significantly in the AD group compared to those in the PF group. These results showed that the changes in the redox state of albumin in the rat model of CKD were similar to those in patients with CKD."}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-10-20"}],"displaytype":"detail","filename":"16_中村博範.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PDF","url":"https://kwmw.repo.nii.ac.jp/record/14918/files/16_中村博範.pdf"},"version_id":"1caf6473-b6f1-4777-bf61-42269fb06b55"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"albumin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"redox state","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"chronic kidney disease（CKD）","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"rat","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"アデニン誘発性慢性腎臓病モデルラットにおける血漿アルブミンの酸化還元状態の評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アデニン誘発性慢性腎臓病モデルラットにおける血漿アルブミンの酸化還元状態の評価","subitem_title_language":"ja"}]},"item_type_id":"1","owner":"23","path":["340"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-10-20"},"publish_date":"2021-10-20","publish_status":"0","recid":"14918","relation_version_is_last":true,"title":["アデニン誘発性慢性腎臓病モデルラットにおける血漿アルブミンの酸化還元状態の評価"],"weko_creator_id":"23","weko_shared_id":-1},"updated":"2024-02-15T05:48:55.748847+00:00"}