{"created":"2023-06-19T10:05:21.253364+00:00","id":14789,"links":{},"metadata":{"_buckets":{"deposit":"70e23746-2d54-407c-9dc2-97dd00a99050"},"_deposit":{"created_by":23,"id":"14789","owners":[23],"pid":{"revision_id":0,"type":"depid","value":"14789"},"status":"published"},"_oai":{"id":"oai:kwmw.repo.nii.ac.jp:00014789","sets":["7:330:332"]},"author_link":["64951","64952","64953","64954","64955","64956","64957","64958"],"control_number":"14789","item_1_alternative_title_20":{"attribute_name":"その他(別言語等)のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Search and Analysis of Food Components with Anti-inflammatory Activity","subitem_alternative_title_language":"en"}]},"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"283","bibliographicPageStart":"279","bibliographicVolumeNumber":"30","bibliographic_titles":[{"bibliographic_title":"川崎医療福祉学会誌"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"奥, 和之","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"64951","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宮田, 富弘","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"64952","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"三浦, 紀称嗣","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"64953","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山口, 大貴","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"64954","nameIdentifierScheme":"WEKO"}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_2":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"短報","subitem_description_type":"Other"}]},"item_1_full_name_7":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"64955","nameIdentifierScheme":"WEKO"}],"names":[{"name":"OKU, Kazuyuki"}]},{"nameIdentifiers":[{"nameIdentifier":"64956","nameIdentifierScheme":"WEKO"}],"names":[{"name":"MIYADA, Tomihiro"}]},{"nameIdentifiers":[{"nameIdentifier":"64957","nameIdentifierScheme":"WEKO"}],"names":[{"name":"MIURA, Kiyoshi"}]},{"nameIdentifiers":[{"nameIdentifier":"64958","nameIdentifierScheme":"WEKO"}],"names":[{"name":"YAMAGUCHI, Daiki"}]}]},"item_1_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15112/00014724","subitem_identifier_reg_type":"JaLC"}]},"item_1_publisher_23":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"川崎医療福祉学会"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN10375470","subitem_source_identifier_type":"NCID"}]},"item_1_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0917-4605","subitem_source_identifier_type":"PISSN"}]},"item_1_text_22":{"attribute_name":"その他(別言語)の雑誌名","attribute_value_mlt":[{"subitem_text_value":"Kawasaki medical welfare journal"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"川崎医療福祉大学医療技術学部臨床栄養学科"},{"subitem_text_value":"川崎医療福祉大学医療技術学部臨床栄養学科"},{"subitem_text_value":"川崎医療福祉大学大学院医療技術学研究科健康科学専攻"},{"subitem_text_value":"川崎医療福祉大学大学院医療技術学研究科健康科学専攻"}]},"item_1_textarea_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_textarea_value":"本研究では，腸管上皮細胞が産生する炎症性サイトカイン分泌を抑制し，抗炎症性を示す食品成分の検索を行った．腸管上皮モデル Caco-2細胞を用いて TNF-αによる細胞障害性とサイトカイン分泌亢進に対する影響について検討したところ，大麦若葉末，ホウレン草の75％エタノール抽出物に細胞障害抑制と炎症性サイトカイン分泌抑制が認められた．また，大麦若葉末およびホウレン草由来糖脂質を添加することによって，細胞障害性および炎症性サイトカイン（IL-6，IL-8）産生が顕著に抑制した．以上の結果から，大麦若葉末由来糖脂質は炎症性腸疾患を抑制することが示唆された．"}]},"item_1_textarea_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"We investigated the effects of Young barley leaf powder (YBLP), spinach and mulberry leafcomponents, and found that glycolipids and beta-glucans suppressed TNF-α-induced cell-cytotoxicity and inflammatory cytokine secretion in human intestinal epithelial-like Caco-2 cells. The increased expression levels of inflammatory cytokineIL-8 by TNF-α was almost completely suppressed by YBLP and spinach glycolipids. Furthermore, the transcriptional activity of human IL-8 promoter was increased by TNF-α treatment, and suppressed by YBLP glycolipids in a dose-dependent manner. These results show that YBLP and spinach glycolipids suppressed TNF-α-induced IL-8 production at the transcriptional level, suggesting that YBLP glycolipids are a promising component in preventing Inflammatory bowel disease."}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-14"}],"displaytype":"detail","filename":"11_奥和之.pdf","filesize":[{"value":"487.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PDF","url":"https://kwmw.repo.nii.ac.jp/record/14789/files/11_奥和之.pdf"},"version_id":"a19f7477-3b94-465d-a5b0-a78bfb752fa0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"young barley leaf powder","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"glycolipid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"inflammatory bowel disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"intestinal cell culture model","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"inflammatory cytokines","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"抗炎症作用を有する食品成分の検索と解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"抗炎症作用を有する食品成分の検索と解析","subitem_title_language":"ja"}]},"item_type_id":"1","owner":"23","path":["332"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-12-14"},"publish_date":"2020-12-14","publish_status":"0","recid":"14789","relation_version_is_last":true,"title":["抗炎症作用を有する食品成分の検索と解析"],"weko_creator_id":"23","weko_shared_id":-1},"updated":"2024-02-20T06:50:36.224582+00:00"}