{"created":"2023-06-19T10:05:16.786315+00:00","id":14679,"links":{},"metadata":{"_buckets":{"deposit":"e6970768-bccc-4461-9e63-67c392daf30c"},"_deposit":{"created_by":21,"id":"14679","owners":[21],"pid":{"revision_id":0,"type":"depid","value":"14679"},"status":"published"},"_oai":{"id":"oai:kwmw.repo.nii.ac.jp:00014679","sets":["7:310:311"]},"author_link":["64456","64457","64458","64459"],"control_number":"14679","item_1_alternative_title_20":{"attribute_name":"その他(別言語等)のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Relationship between Prenatal Stress and Abnormal Behaviors of Mice Offspring","subitem_alternative_title_language":"en"}]},"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"98","bibliographicPageStart":"91","bibliographicVolumeNumber":"29","bibliographic_titles":[{"bibliographic_title":"川崎医療福祉学会誌"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"藤原, 有子","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"上野, 浩司","creatorNameLang":"ja"}],"nameIdentifiers":[{}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_2":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著","subitem_description_type":"Other"}]},"item_1_full_name_7":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"FUJIWARA, Yuko"}]},{"nameIdentifiers":[{}],"names":[{"name":"UENO, Hiroshi"}]}]},"item_1_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15112/00014618","subitem_identifier_reg_type":"JaLC"}]},"item_1_publisher_23":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"川崎医療福祉学会"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN10375470","subitem_source_identifier_type":"NCID"}]},"item_1_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0917-4605","subitem_source_identifier_type":"PISSN"}]},"item_1_text_22":{"attribute_name":"その他(別言語)の雑誌名","attribute_value_mlt":[{"subitem_text_value":"Kawasaki medical welfare journal"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"川崎医療福祉大学医療技術学部健康体育学科"},{"subitem_text_value":"川崎医療福祉大学医療技術学部臨床検査学科"}]},"item_1_textarea_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_textarea_value":"妊娠中のストレスや感染は，統合失調症や注意欠陥多動性障害などの精神神経疾患の危険因子であることが知られている．しかしながら，妊娠中のストレスの程度やストレスを受ける時期によって出 生児への影響がどのように変化するのかは明らかになっていない．本研究では，妊娠後期の雌マウスの慢性的なストレス負荷によって生まれてきた仔マウスの成熟後にどのような行動異常が生じるのかを一連の行動実験を実施して調べた．雌マウスは妊娠後期から出産するまで，毎日3度の身体的ストレスを受けた．出生した仔マウスの成熟後に様々な行動実験を行い，行動異常を明らかにした．その結果，妊娠中にストレスを受けた仔マウスはコントロールマウスと比較して身体的な特徴に明らかな違いはなかった．しかし，精神神経疾患様の行動異常（不安様行動の増加，活動量の増加，社会性の低下）を示した．これらの結果は，妊娠後期における母マウスの慢性的なストレスが仔マウスの神経心理発達に影響を与えることを示している．妊娠中の母親のストレスが精神神経疾患の発症危険因子として重要である可能性が示唆された．"}]},"item_1_textarea_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"Stress and infection during pregnancy are known to be a risk factor for neuropsychiatric disorders such as schizophrenia and attention-deficit hyperactivity disorder. However, it has not been clarified how the influence on a fetus will change by the degree of stress or the period when a mother receives stress during pregnancy. In this study, we examined what behavioral abnormalities occur after offspring mice born from chronically stressed female mice in late pregnancy matured. Female mice received physical stress three times daily from late pregnancy to delivery. After newborn mice matured, we conducted various behavioral experiments to clarify behavioral abnormalities. As a result, the offspring mice born from stressed mice during pregnancy had no significant difference in physical characteristics compared to control mice. The offspring mice had been stressed who during pregnancy showed behavioral abnormalities like neuropsychiatric disorder; increased anxiety - like behavior, increased activity level or decreased sociality. These results indicate that the chronic stress of the female mice in the late pregnancy affects the neuropsychological development of the offspring. This suggests that stress of mothers during pregnancy may be an important risk factor for the development of neuropsychiatric disorders."}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-06"}],"displaytype":"detail","filename":"12_藤原有子 他1名.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PDF","url":"https://kwmw.repo.nii.ac.jp/record/14679/files/12_藤原有子 他1名.pdf"},"version_id":"b1d8d8e3-6152-46be-9a30-4e053d915f73"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"maternal stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mouse","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"abnormal behavior","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"offspring","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"マウスにおける妊娠後期の慢性ストレスは仔マウスの行動に影響を与える","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マウスにおける妊娠後期の慢性ストレスは仔マウスの行動に影響を与える","subitem_title_language":"ja"}]},"item_type_id":"1","owner":"21","path":["311"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-01-06"},"publish_date":"2020-01-06","publish_status":"0","recid":"14679","relation_version_is_last":true,"title":["マウスにおける妊娠後期の慢性ストレスは仔マウスの行動に影響を与える"],"weko_creator_id":"21","weko_shared_id":-1},"updated":"2024-02-26T02:11:46.530745+00:00"}