{"created":"2023-06-19T10:05:02.352366+00:00","id":14320,"links":{},"metadata":{"_buckets":{"deposit":"b8b31139-5a56-4564-827f-1c140ed027f3"},"_deposit":{"created_by":18,"id":"14320","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"14320"},"status":"published"},"_oai":{"id":"oai:kwmw.repo.nii.ac.jp:00014320","sets":["7:267:268"]},"author_link":["63386","63388","63389","63390","63385","63387"],"item_1_alternative_title_20":{"attribute_name":"その他(別言語等)のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Evaluation for Absorption and Metabolism of Short Chain Fatty Acids in the Large Intestine, Using 13C-Breath Test in Rats"}]},"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"57","bibliographicPageStart":"49","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"川崎医療福祉学会誌"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"若狭, 麻未"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"三浦, 紀称嗣"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"宮田, 富弘"}],"nameIdentifiers":[{}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_2":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著","subitem_description_type":"Other"}]},"item_1_full_name_7":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"WAKASA, Asami"}]},{"nameIdentifiers":[{}],"names":[{"name":"MIURA, Kiyoshi"}]},{"nameIdentifiers":[{}],"names":[{"name":"MIYADA, Tomihiro"}]}]},"item_1_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15112/00014286","subitem_identifier_reg_type":"JaLC"}]},"item_1_publisher_23":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"川崎医療福祉学会"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN10375470","subitem_source_identifier_type":"NCID"}]},"item_1_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0917-4605","subitem_source_identifier_type":"ISSN"}]},"item_1_text_22":{"attribute_name":"その他(別言語)の雑誌名","attribute_value_mlt":[{"subitem_text_value":"Kawasaki medical welfare journal"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"原著"}]},"item_1_textarea_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_textarea_value":"　本研究では，ラットにおいて, 短鎖脂肪酸（SCFAs）の大腸からの吸収や代謝について13C 呼気分析法を用いて検討した．大腸内に13C でラベルされたSCFAs を投与するためにラットに回腸瘻孔を設置した．ラットを一晩絶食させた後，15μmol～45μmol の［1-13C］酢酸Na，［1-13C］プロピオン酸Na，あるいは［1-13C］酪酸Na を含む生理食塩水0.2 ml を経口投与あるいは大腸内投与した．呼気は一定間隔で収集し，呼気中13CO2を赤外線分光分析装置で測定した．酢酸の経口投与あるいは大腸内投与後，直ちに13CO2が増加し，その後徐々に減少した．呼気中13CO2の最大値（Cmax）は，経口投与と大腸内投与の両者で用量依存的に増加したが、経口投与より大腸投与の方が有意に低値を示した．また，Cmax に到達するまでの時間（Tmax）は，経口投与に比べ大腸内投与で有意に遅延した．酢酸と酪酸に比べプロピオン酸ではCmax が有意に高値を示し，大腸からの吸収や代謝過程にSCFAs 間で大きな違いがあることが示唆された．測定開始日から3週間後までの実験期間において，Cmax にはSCFAs 間における差異が認められたが，いずれのSCFA でもCmax はラットの成長に伴って低下する傾向にあった. 本研究の結果は，13C 呼気分析法が生体位における大腸からのSCFAs の吸収や代謝の評価に有用であることを示している．"}]},"item_1_textarea_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"　Rats were established an external ileal fistula for administration of 13C-labeled short chain fatty acids (SCFAs) to the large intestine. Rats received intracecal infusion or oral infusion of 15μmol of 13C-acetate. The 13C breath test was performed. An expired air was collected at appropriate intervals and a concentration of 13CO2 in the air was measured with an infrared analyzer. The expired 13CO2 increased rapidly after the intracecal infusion or the oral infusion of the 13C-acetate, and then decreased gradually. Maximum concentration (Cmax) of 13CO2 in the expired air was significantly lower in the intracecal infusion than in the oral infusion. The Cmax increased in a dose dependent manner in both the intracecal infusin and the oral infusin. When rats received intracecal infusion of the 13C-acetate, 13C-propionate or 13C-butyrate, the Cmax was significantly higher in the 13C-propionate than in the others. The Cmax in SCFAs except for propionate tended to decline during the experimental 3 weeks. These results suggest that absorption and post-absorptive metabolism of propionate differ from those of acetate and butyrate in the large intestine. The 13C breath test may be useful in studies on absorption and metabolisms of SCFAs in the whole body."}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-12-09"}],"displaytype":"detail","filename":"06　若狭麻未.pdf","filesize":[{"value":"620.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PDF","url":"https://kwmw.repo.nii.ac.jp/record/14320/files/06　若狭麻未.pdf"},"version_id":"06d14c09-a640-4eb5-a902-420accff62ee"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"short chain fatty acids","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"acetate","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"propionate","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"13C-breath test","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"stable isotopes","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ラットにおける13C 呼気分析を用いた大腸内短鎖脂肪酸の吸収と代謝の評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ラットにおける13C 呼気分析を用いた大腸内短鎖脂肪酸の吸収と代謝の評価"}]},"item_type_id":"1","owner":"18","path":["268"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-12-09"},"publish_date":"2016-12-09","publish_status":"0","recid":"14320","relation_version_is_last":true,"title":["ラットにおける13C 呼気分析を用いた大腸内短鎖脂肪酸の吸収と代謝の評価"],"weko_creator_id":"18","weko_shared_id":18},"updated":"2023-06-19T10:33:36.232617+00:00"}