{"created":"2023-06-19T10:04:23.615481+00:00","id":13242,"links":{},"metadata":{"_buckets":{"deposit":"65c1aa8d-e809-4981-bd3a-4445a94cc033"},"_deposit":{"created_by":23,"id":"13242","owners":[23],"pid":{"revision_id":0,"type":"depid","value":"13242"},"status":"published"},"_oai":{"id":"oai:kwmw.repo.nii.ac.jp:00013242","sets":["7:193:194"]},"author_link":["61717","65866","65867","61719","61718","65865"],"item_1_alternative_title_20":{"attribute_name":"その他(別言語等)のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"The Protective Effects of L-Carnitine on Cardiac Mitochondria under Fatty Acid Treatment"}]},"item_1_alternative_title_5":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_alternative_title":"L カルニチン ノ シボウサン ニ タイスル シンキン ミトコンドリア ホゴ サヨウ"}]},"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"36","bibliographicPageStart":"27","bibliographicVolumeNumber":"23","bibliographic_titles":[{"bibliographic_title":"川崎医療福祉学会誌"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"矢野, 博己"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Michael, J.Kremenik"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"長野, 隆男"}],"nameIdentifiers":[{}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_17":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_description":"http://www.kawasaki-m.ac.jp/soc/mw/journal/jp/2013-j23-1/P27-36_yano.pdf","subitem_description_type":"Other"}]},"item_1_description_2":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"総説","subitem_description_type":"Other"}]},"item_1_description_3":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Review Article","subitem_description_type":"Other"}]},"item_1_full_name_7":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"Yano, Hiromi"}]},{"nameIdentifiers":[{}],"names":[{"name":"Kremenik, Michael J."}]},{"nameIdentifiers":[{}],"names":[{"name":"Nagano, Takao"}]}]},"item_1_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15112/00013231","subitem_identifier_reg_type":"JaLC"}]},"item_1_publisher_23":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"川崎医療福祉学会"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN10375470","subitem_source_identifier_type":"NCID"}]},"item_1_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09174605","subitem_source_identifier_type":"ISSN"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Health and Sports Science, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare"},{"subitem_text_language":"en","subitem_text_value":"Department of Health and Sports Science, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare"},{"subitem_text_language":"en","subitem_text_value":"Department of Clinical Nutrition, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare"}]},"item_1_text_22":{"attribute_name":"その他(別言語)の雑誌名","attribute_value_mlt":[{"subitem_text_value":"Kawasaki medical welfare journal"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"川崎医療福祉大学医療技術学部健康体育学科"},{"subitem_text_value":"川崎医療福祉大学医療技術学部健康体育学科"},{"subitem_text_value":"川崎医療福祉大学医療技術学部臨床栄養学科"}]},"item_1_textarea_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_textarea_value":"循環器系疾患のリスクは高い血清脂肪酸レベルと関連している場合がある.近年,脂肪酸ミトコンドリア機能に影響を与え,その結果,細胞をアポトーシスに誘導することが示されるようになって きたが,ミトコンドリアの脂肪酸取り込みに不可欠とされる L- カルニチンには,こうした脂肪酸誘 導性ミトコンドリア機能障害を軽減させ,心筋細胞アポトーシスを減衰させる働きがあるようである. 本稿では,脂肪酸によって誘発されるミトコンドリア膜透過性遷移,およびその結果もたらされる心 筋ミトコンドリアからのアポトーシス誘導因子シトクロム c の放出に対する L- カルニチンの抑制効 果について解説する."}]},"item_1_textarea_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"Cardiovascular risks are frequently accompanied by high serum fatty acid levels. Although recent studies have shown that fatty acids affect mitochondrial function and induce cell apoptosis, L-carnitine is essential for the uptake of fatty acids by mitochondria, and may attenuate the mitochondrial dysfunction and apoptosis of cardiocytes. In this review, we explain the role of L-carnitine in the prevention on fatty acid-induced mitochondrial membrane permeability transition and cytochrome c release using isolated cardiac mitochondria."}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-01-31"}],"displaytype":"detail","filename":"P27-36_yano.pdf","filesize":[{"value":"5.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PDF","url":"https://kwmw.repo.nii.ac.jp/record/13242/files/P27-36_yano.pdf"},"version_id":"199031d6-d032-434d-8cff-684d09a56c63"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"palmitoyl-CoA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"β -oxidation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cytochrome c","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"heart","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"L-カルニチンの脂肪酸に対する心筋ミトコンドリア保護作用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"L-カルニチンの脂肪酸に対する心筋ミトコンドリア保護作用"}]},"item_type_id":"1","owner":"23","path":["194"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-01-01"},"publish_date":"2013-01-01","publish_status":"0","recid":"13242","relation_version_is_last":true,"title":["L-カルニチンの脂肪酸に対する心筋ミトコンドリア保護作用"],"weko_creator_id":"23","weko_shared_id":23},"updated":"2023-06-19T10:37:25.484550+00:00"}