{"created":"2023-06-19T10:04:21.325007+00:00","id":13172,"links":{},"metadata":{"_buckets":{"deposit":"181367b9-a33c-4a0f-af3e-2bf911208fe4"},"_deposit":{"created_by":23,"id":"13172","owners":[23],"pid":{"revision_id":0,"type":"depid","value":"13172"},"status":"published"},"_oai":{"id":"oai:kwmw.repo.nii.ac.jp:00013172","sets":["7:29:37"]},"author_link":["61181","61179","65727","65728","65726","61180"],"item_1_alternative_title_20":{"attribute_name":"その他(別言語等)のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Development of a Murine Model for Wheat-dependent Exercise-induced Anaphylaxis Using B10.A Mice"}]},"item_1_alternative_title_5":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_alternative_title":"B10A マウス オ モチイタ コムギ イゾンセイ ウンドウ ユウハツ アナフィラキシー モデルケイ ノ サクセイ"}]},"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"410","bibliographicPageStart":"405","bibliographicVolumeNumber":"20","bibliographic_titles":[{"bibliographic_title":"川崎医療福祉学会誌"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田中, 守"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山田, 作夫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"長野, 隆男"}],"nameIdentifiers":[{}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_17":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_description":"http://www.kawasaki-m.ac.jp/soc/mw/journal/jp/2011-j20-2/405-410_tanaka.pdf","subitem_description_type":"Other"}]},"item_1_description_2":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著","subitem_description_type":"Other"}]},"item_1_description_3":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Original Paper","subitem_description_type":"Other"}]},"item_1_full_name_7":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"Tanaka, Mamoru"}]},{"nameIdentifiers":[{}],"names":[{"name":"Yamada, Sakuo"}]},{"nameIdentifiers":[{}],"names":[{"name":"Nagano, Takao"}]}]},"item_1_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15112/00013161","subitem_identifier_reg_type":"JaLC"}]},"item_1_publisher_23":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"川崎医療福祉学会"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN10375470","subitem_source_identifier_type":"NCID"}]},"item_1_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09174605","subitem_source_identifier_type":"ISSN"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Doctoral Program in Health Science, Graduate School of Health Science and Technology, Kawasaki University of Medical Welfare"},{"subitem_text_language":"en","subitem_text_value":"Department of Clinical Nutrition, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare・Department of Microbiology, Kawasaki Medical School"},{"subitem_text_language":"en","subitem_text_value":"Department of Clinical Nutrition, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare"}]},"item_1_text_22":{"attribute_name":"その他(別言語)の雑誌名","attribute_value_mlt":[{"subitem_text_value":"Kawasaki medical welfare journal"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"川崎医療福祉大学医療技術学研究科健康科学専攻"},{"subitem_text_value":"川崎医療福祉大学医療技術学部臨床栄養学科・川崎医科大学微生物学教室"},{"subitem_text_value":"川崎医療福祉大学医療技術学部臨床栄養学科"}]},"item_1_textarea_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_textarea_value":"小麦依存性運動誘発アナフィラキシー(WDEIA, Wheat-Dependent Exercise-Induced Anaphylaxis)は,小麦製品を摂取したのみでは症状がみられず,運動が加わった場合に限り誘発される食物アレルギーの特殊病型である.本研究ではB10.Aマウスを用いたWDEIAモデル系の作製を試みた.B10.Aマウスを3群に分け,マウスの腹腔内にグリアジン画分を含むアルミニウムアジュバントを7日毎に4回,5回,6回免疫し,感作マウスを作製した.感作成立の判定は,血清中グリアジン特異IgE値を指標とし,ELISA法により求めた.感作マウスにグリアジン画分(0.1g/匹)を経口投与後,30分間のトレッドミル運動(傾斜20%,速度15m/分)を負荷し,その後,直腸温と自発運動量をアナフィラキシーの指標として測定した.グリアジン特異IgE値は,5回以上の免疫群で有意な上昇が観察された.体温と自発運動量は,6回免疫群で有意な低下が観察された.以上の結果から,WDEIAモデル系は6回以上の免疫を行うことが必要であると考えられた."}]},"item_1_textarea_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"Wheat-dependent exercise-induced anaphylaxis(WDEIA)is a distinct form of food allergy induced by physical exercise. In this study, for the purpose of making a mouse model of WDEIA, we divided B10.A mice into three groups. The mice were intraperitoneally injected with gliadin/Alum four, five or six times at an interval of 7 days;i.e. a four injection group, five injection group, six injection group. The specific anti-gliadin IgE in serum was evaluated by ELISA. To assess anaphylaxis symptoms, rectal temperature and voluntary physical activity were examined. The sensitized mice were orally challenged with 0.1g gliadin, and then treated with forced runs on a treadmill for 30min(15m/min and 20% gradient). After the exercise, rectal temperature was examined and then voluntary physical activity was also monitored. The amount of gliadin-specific IgE in the five injection group and six injection group was significantly higher than before sensitization. The mice showed a significant decrease in the rectal temperature and voluntary physical activity, especially in the six injection group. We concluded that the murine model of WDEIA, sensitized at more than six injections by gliadin with alum, is useful for research of WDEIA."}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-01-31"}],"displaytype":"detail","filename":"405-410_tanaka.pdf","filesize":[{"value":"481.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PDF","url":"https://kwmw.repo.nii.ac.jp/record/13172/files/405-410_tanaka.pdf"},"version_id":"36bd1a0d-61cc-4f51-9cd4-317f71b5e8df"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"mouse model","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"wheat-dependent exercise-induced anaphylaxis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"gliadin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IgE","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"B10.Aマウスを用いた小麦依存性運動誘発アナフィラキシーモデル系の作製","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"B10.Aマウスを用いた小麦依存性運動誘発アナフィラキシーモデル系の作製"}]},"item_type_id":"1","owner":"23","path":["37"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-01-01"},"publish_date":"2011-01-01","publish_status":"0","recid":"13172","relation_version_is_last":true,"title":["B10.Aマウスを用いた小麦依存性運動誘発アナフィラキシーモデル系の作製"],"weko_creator_id":"23","weko_shared_id":23},"updated":"2023-06-19T10:38:51.669249+00:00"}