{"created":"2023-06-19T10:04:18.411667+00:00","id":13099,"links":{},"metadata":{"_buckets":{"deposit":"4f55b7ea-d866-4257-94f9-fac79ea6cf29"},"_deposit":{"created_by":17,"id":"13099","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"13099"},"status":"published"},"_oai":{"id":"oai:kwmw.repo.nii.ac.jp:00013099","sets":["7:28:39"]},"author_link":["60563","60562"],"item_1_alternative_title_20":{"attribute_name":"その他(別言語等)のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Another Biological Activity of Asbestos or Silica to Induce Immunological Disorders in Human Beings"}]},"item_1_alternative_title_5":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_alternative_title":"アスベスト メンエキ イジョウ ノ ユウハツ トイウ キガカリ"}]},"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"268","bibliographicPageStart":"261","bibliographicVolumeNumber":"19","bibliographic_titles":[{"bibliographic_title":"川崎医療福祉学会誌"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"植木, 絢子"}],"nameIdentifiers":[{"nameIdentifier":"60562","nameIdentifierScheme":"WEKO"}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_17":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_description":"http://www.kawasaki-m.ac.jp/soc/mw/journal/jp/2010-j19-2/2_ueki.pdf","subitem_description_type":"Other"}]},"item_1_description_2":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"論説","subitem_description_type":"Other"}]},"item_1_description_3":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_1_full_name_7":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"60563","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ueki, Ayako"}]}]},"item_1_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15112/00013088","subitem_identifier_reg_type":"JaLC"}]},"item_1_publisher_23":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"川崎医療福祉学会"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN10375470","subitem_source_identifier_type":"NCID"}]},"item_1_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0917-4605","subitem_source_identifier_type":"ISSN"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Rehabilitation, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare"}]},"item_1_text_22":{"attribute_name":"その他(別言語)の雑誌名","attribute_value_mlt":[{"subitem_text_value":"Kawasaki medical welfare journal"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"川崎医療福祉大学医療技術学部リハビリテーション学科"}]},"item_1_textarea_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_textarea_value":"人の疾病について考える際に,いわゆる自然発生的(idiopathic)な発症と既知の環境因子に起因する疾患が,特別の理由もなく区別して扱われてきた様に思われる.しかし,本稿で扱った珪酸や珪酸塩化合物のみでなく,様々な物質について,人は或るときは職業上の,またある時は生活環境中での曝露により,絶えず疾病への危険にさらされている可能性が重要視されるようになり,疑わしい物質が挙げられている.これは,細菌やカビなどによる感染症の一部が,比較的容易に治療可能となった結果見えてきた現実ともいえる.そしてまた,それらに対する個人の感受性(遺伝的素因)差の重要性も認識されるようになった.珪酸や珪酸塩化合物への曝露による作業関連疾患(本稿では免疫異常に着目するが)は,環境因子が人体に作用した結果生じる人体の変化,奇しくも人体実験にも似た,得がたい貴重な(そして重い)資料について,目撃したことを広く伝えてゆくことが,これらの資料に接することを許された者の務めと考え,まとめたものである."}]},"item_1_textarea_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"The exposure to silica and related substances such as asbestos or silicone, used in plastic surgery, has been known to induce autoimmune reactions. This report is intended to summarize our results which suggest a suppressed apoptosis of lymphocytes through the Fas-Fas ligand system in silicosis or asbestosis patients, and speculate on the effects of silica on inappropriated cell survival which could induce autoimmune reactions. From several results, we concluded that silica and related substances play an important role in inducing autoimmunity by repeated polyclonal activation of human T lymphocytes and the suppression of apoptosis among activated lymphocytes."}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-01-31"}],"displaytype":"detail","filename":"2_ueki.pdf","filesize":[{"value":"518.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PDF","url":"https://kwmw.repo.nii.ac.jp/record/13099/files/2_ueki.pdf"},"version_id":"5e0fe89b-f6e2-4ee5-9270-2df732f4bc93"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"asbestos","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"immunological disorders","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"human beings","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"アスベスト : 免疫異常の誘発という気がかり","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アスベスト : 免疫異常の誘発という気がかり"}]},"item_type_id":"1","owner":"17","path":["39"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-01-01"},"publish_date":"2010-01-01","publish_status":"0","recid":"13099","relation_version_is_last":true,"title":["アスベスト : 免疫異常の誘発という気がかり"],"weko_creator_id":"17","weko_shared_id":17},"updated":"2023-06-19T10:41:22.018338+00:00"}