{"created":"2023-06-19T10:04:09.673266+00:00","id":12865,"links":{},"metadata":{"_buckets":{"deposit":"1ab99a30-f788-4b4a-9664-b08f01b20d09"},"_deposit":{"created_by":17,"id":"12865","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"12865"},"status":"published"},"_oai":{"id":"oai:kwmw.repo.nii.ac.jp:00012865","sets":["7:25:44"]},"author_link":["58624","58626","58627","58623","58625","58628"],"item_1_alternative_title_20":{"attribute_name":"その他(別言語等)のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Wheat Protein as an Allergen : Wheat-Dependent Exercise-Induced Anaphylaxis"}]},"item_1_alternative_title_5":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_alternative_title":"コムギ タンパクシツ ト アレルギー : コムギ イゾンセイ ウンドウ ユウハツ アナフィラキシー ニチュウモク シテ"}]},"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"19","bibliographicPageStart":"11","bibliographicVolumeNumber":"16","bibliographic_titles":[{"bibliographic_title":"川崎医療福祉学会誌"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"香西, はな"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"矢野, 博己"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"加藤, 保子"}],"nameIdentifiers":[{}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_17":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_description":"http://www.kawasaki-m.ac.jp/soc/mw/journal/jp/2006-j16-1/04_kozai.pdf","subitem_description_type":"Other"}]},"item_1_description_2":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"総説","subitem_description_type":"Other"}]},"item_1_full_name_7":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"Kozai, Hana"}]},{"nameIdentifiers":[{}],"names":[{"name":"Yano, Hiromi"}]},{"nameIdentifiers":[{}],"names":[{"name":"Kato, Yasuko"}]}]},"item_1_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15112/00012854","subitem_identifier_reg_type":"JaLC"}]},"item_1_publisher_23":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"川崎医療福祉学会"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN10375470","subitem_source_identifier_type":"NCID"}]},"item_1_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0917-4605","subitem_source_identifier_type":"ISSN"}]},"item_1_text_22":{"attribute_name":"その他(別言語)の雑誌名","attribute_value_mlt":[{"subitem_text_value":"Kawasaki medical welfare journal"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"川崎医療福祉大学医療技術学研究科健康科学専攻"},{"subitem_text_value":"川崎医療福祉大学医療技術学部健康体育学科"},{"subitem_text_value":"川崎医療福祉大学医療技術学研究科健康科学専攻"}]},"item_1_textarea_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_textarea_value":"現在,小麦はアレルギーを引き起こす三大食品の一つとされており,更に食物依存性運動誘発アナフィラキシーの最多原因食品としても注目されている.これまで,小麦アレルギーとしては,Baker's Asthmaやセリアック病などがよく知られており,原因タンパク質としてはそれぞれ塩溶性タンパク質,グリアジンであるとの報告が多い.近年問題となっている小麦依存性運動誘発アナフィラキシー(WDEIA)に関しては,ω-グリアジンであると報告されている.WDEIAの発症メカニズム解明のため,我々は,B10.Aマウスと卵白リゾチーム(Ly)を用いて,モデル実験動物系を確立した.各小麦タンパク質で感作したB10.Aマウスのアレルゲン投与後の疲労困憊運動時間は非感作群と比較して短く,更に,グリアジン次いでグルテニン群の小腸粘膜上皮組織の損傷は激しいものであった.マウスを用いて検討したWDEIAの原因タンパク質はグリアジン次いでグルテニンである可能性が高く,これらのタンパク質が小腸粘膜上皮組織を著しく損傷させ,体内へのアレルゲンの吸収も促進,更に,運動がこの損傷を増悪させることが考えられた.このような小腸粘膜上皮組織の損傷は,セリアック病でも観察され,セリアック病では,グリアジンの消化生成物であるペプチドがかなりの毒性ペプチドであることが報告されてきており,このようなグリアジンタンパク質の特性とWDEIAとの関係も示唆されるものであった.本報告では,小麦タンパク質とWDEIAに関して,これまで進められてきている研究の流れと,原因小麦タンパク質に関する情報を解説した."}]},"item_1_textarea_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_textarea_language":"en","subitem_textarea_value":"Wheat flour is one of the three major food-allergens. Numerous reports indicate that salt-soluble wheat proteins cause baker's asthma and gliadin causes celiac disease. Moreover, Food-dependent exercise-induced anaphylaxis (FDEIA) is due to wheat flour in many cases. When B10.A mice which serve as useful models for studying the immunological mechanism of wheat-dependent exercise-induced anaphylaxis (WDEIA), were sensitized with several fractions of wheat protein, their running times until exhaustion were remarkably shortened, and high levels of intestinal erosion were found. These gastrointestinal mucosal lesions have also been observed in celiac disease. The major allergens of WDEIA might be gliadin and glutenin. Recently, it was reported that the peptides of digested gliadin showed toxicity in a study of celiac disease. It was suggested that the toxic peptides generated during the digestion of gliadin could cause not only celiac disease but also WDEIA. This review focused on previous WDEIA and wheat protein studies."}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-01-31"}],"displaytype":"detail","filename":"04_kozai.pdf","filesize":[{"value":"514.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PDF","url":"https://kwmw.repo.nii.ac.jp/record/12865/files/04_kozai.pdf"},"version_id":"8a775455-a830-4454-9603-2ee2cf40a74f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"wheat","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"gliadin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"wheat-dependent exercise-induced anaphylaxis WDEIA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"B10. A mice","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"小麦タンパク質とアレルギー : 小麦依存性運動誘発アナフィラキシーに注目して","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"小麦タンパク質とアレルギー : 小麦依存性運動誘発アナフィラキシーに注目して"}]},"item_type_id":"1","owner":"17","path":["44"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-01-01"},"publish_date":"2006-01-01","publish_status":"0","recid":"12865","relation_version_is_last":true,"title":["小麦タンパク質とアレルギー : 小麦依存性運動誘発アナフィラキシーに注目して"],"weko_creator_id":"17","weko_shared_id":17},"updated":"2023-06-19T10:49:03.641773+00:00"}